we aimed to investigate the effect of radix angelicae emulsion on serum cytokines and Th17/Treg balance in nasal mucosa of mice with allergic rhinitis. C57BL/6 mice were randomly divided into normal group, model group and radix angelicae group. The model of allergic rhinitis was induced by ovalbumin. The pathological changes of nasal mucosa were observed by hematoxylin-eosin (HE) staining. The ratio of Th17 and Treg in peripheral blood was detected by flow cytometry. The levels of IgE, IL-6, IL-10, IL-17 and transforming growth factor β1 (TGF-β1) in serum and nasal lavage fluid were detected by ELISA. The expressions of IL-17 and TGF-β1 mRNA in nasal mucosa lavage fluid were detected by RT-PCR. The HE staining results showed that, compared with the normal group, the model group had a large number of eosinophil-based inflammatory cell infiltration; and compared with the model group, the nasal mucosa epithelial cells in the radix angelicae group were neatly arranged, the epithelial damage was slight, and the eosinophil infiltration was relatively cut back. Compared with the normal group, the proportion of Th17 in the model group increased（P<0.01）whereas the proportion of Treg decreased（P<0.01）, and the levels of IL-6 and IL-17 in serum and nasal lavage fluid increased significantly（P<0.01）, and the levels of IL-10 and TGF-β1 decreased significantly（P<0.01）. Compared with the model group, the proportion of Th17 in the radix angelicae group decreased（P<0.01）, the proportion of Treg increased（P<0.05）, the levels of IL-6 and IL-17 in serum and nasal lavage fluid were significantly decreased（P<0.01）, and the levels of IL-10 and TGF-β1 were significantly increased（P<0.05）. In summary, radix angelicae can alleviate the nasal mucosa damage of allergic rhinitis mice, probably by restoring Th17/Treg balance.