circular RNA (circ_RNA) is a special type of endogenous regulatory RNA with a closed circular structure. It functions as a "molecular sponge" of miRNA as well as a regulator of gene transcription and expression, making it a critical component in the occurrence and development of many diseases. In recent years, multiple studies confirm that circ_RNAs are differentially expressed in systemic lupus erythematosus （SLE） patients and normal healthy people, and some circ_RNAs are involved in the pathological process of SLE. Therefore, circ_RNAs are potential biomarkers for early diagnosis and prognosis assessment of SLE, as well as therapeutic targets. This review summarizes the research progress of circ_RNA in SLE and aims to provide new directions for the diagnosis, prognosis, and treatment of SLE.