Hepatocellular carcinoma (HCC) is one of the most common malignancies, and the main risk factor for HCC is HBV infection. Hepatitis B virus X protein (HBx) is a key regulator of HBV-associated HCC and can promote tumorigenesis. It has been reported that many long non-coding RNA (lncRNA) contribute to the HCC development, mainly by promoting HBV replication, up-regulating oncogenes expression, or down-regulating the expression of tumor suppressors.Some lncRNA can also act directly as tumor suppressors, which have been extensively studied as disease-treating targets.In this review, we will discuss the role of HBx-regulated lncRNA in HBV-induced HCC and summarize the mechanisms of tumorigenesis and the development of cancer.