The important role of mast cell-derived mediators in the activation of the NLRP3 inflammasome during allergic inflammatory response
PAN Yue-yue, SHU Wen, YIN Yue, CUI Ze-lin, LIAO Huan-jin
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Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
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Received
Published
2023-12-04
2025-03-30
Issue Date
2025-03-27
Abstract
As an integral component of the innate immune system,mast cells (MC) are ubiquitously distributed throughout the skin and mucosal tissues. Upon activation by exogenous or endogenous stimuli, these cells rapidly secrete intracellular mediators, including cytokines, proteases, and lipids, thereby playing a crucial role in the defense against bacterial, viral, and parasitic infections, as well as in mediating allergic inflammatory responses. The NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome is a critical element of innate immunity, significantly contributing to the body's defense against bacterial and viral infections, and allergen-induced inflammatory responses. Furthermore, it represents a promising therapeutic target for the treatment of various inflammatory diseases.While mast cells and NLRP3 are both integral to the processes underlying allergic inflammatory responses, the mechanisms governing mast cell activation, NLRP3 activation and expression, as well as the regulatory interactions between these components in the context of allergic inflammation remain inadequately elucidated. This review systematically summarizes and discusses the role of mast cell activation and the mediator releasing in modulating NLRP3 activation and expression in the context of allergic inflammatory responses. The objective is to elucidate the mechanisms by which mast cells regulate allergic inflammation, thereby enhancing the comprehensive understanding of the signaling pathways involved in allergic inflammatory responses. This review aims to provide a theoretical foundation for the development of anti-inflammatory treatment strategies and combination therapies.
PAN Yue-yue, SHU Wen, YIN Yue, CUI Ze-lin, LIAO Huan-jin.
The important role of mast cell-derived mediators in the activation of the NLRP3 inflammasome during allergic inflammatory response. Current Immunology. 2025, 45(2): 198