为评价血清IL-6、IL-10、TNF-α和血清铁蛋白（serum ferritin， SF）在全身型幼年特发性关节炎（systemic-onset juvenile idiopathic arthritis， SoJIA）和川崎病（kawasaki disease， KD）患儿鉴别诊断中的价值，选取在南京医科大学附属儿童医院就诊的SoJIA、KD患儿及健康体检儿童各53例，分别检测患儿治疗前及健康对照组儿童血清IL-6、IL-10、TNF-α和SF的含量，以及血液白细胞（white blood cell， WBC）、CRP和ESR的水平，比较上述指标在各组间的差异。结果显示，SoJIA组和KD组患儿血液WBC、CRP、ESR、IL-6、IL-10、TNF-α等指标均明显高于健康对照组；SoJIA组患儿SF和CRP含量明显高于KD组，而IL-10水平明显低于KD组。由此，联合检测血液中IL-10、SF、CRP等指标，可以为SoJIA和KD的早期鉴别诊断提供参考，减少误判。

To evaluate the value of IL-6, IL-10, TNF-α and serum ferritin (SF) in differential diagnosis of systemic-onset juvenile idiopathic arthritis (SoJIA) and Kawasaki disease (KD), each of 53 children with SoJIA, KD and healthy children were selected in Children's Hospital of Nanjing Medical University. Blood concentrations of IL-6, IL-10, TNF-α, white blood cell（WBC）, CRP, ESR and SF were compared in children with the diseases and healthy children. The results showed that blood concentrations of WBC, CRP, ESR, IL-6, IL-10 and TNF-α in SoJIA group and KD group were significantly higher than those in healthy children. Blood concentrations of SF and CRP in SoJIA were significantly higher than those in KD children. Serum concentrations of IL-10 in children with SoJIA significantly lower than those in KD children. Thus, combined detection of blood IL-10, SF, CRP can be used for early clinical differential diagnosis of SoJIA and KD.