为探究IL-33与受体抑癌蛋白2(suppression of tumorigenicity 2，ST2)及相关细胞因子在非小细胞肺癌（non-small cell lung cancer，NSCLC）患者中的作用，收集30例NSCLC患者样本为病例组，同时收集40例健康者为对照组，采用实时荧光定量PCR法和免疫组化法检测NSCLC组织中IL-33和ST2的mRNA与蛋白水平；ELISA检测样本血清中IL-33/可溶性ST2(soluble ST2, sST2)、IFN-γ、IL-4、IL-10和IL-17A的水平；Pearson法分析NSCLC患者血清中IL-33与IL-4、IFN-γ、IL-10、IL-17A的相关性。结果显示，与对照组相比，NSCLC患者病灶组织中IL-33和ST2的mRNA与蛋白水平均显著升高（P＜0.05）；患者血清中IL-33、sST2、IL-10、IL-17A和IL-4的水平显著升高，IFN-γ水平显著降低（P＜0.05）；患者血清中IL-33与IL-4、IL-10的水平呈显著正相关（r=0.65，P＜0.01；r=0.77，P＜0.01），与IFN-γ水平呈显著负相关（r=－0.82，P＜0.01），而与IL-17A的水平不相关。由此，IL-33与受体ST2在NSCLC患者中表达增高可能引起Th1/Th2细胞因子分泌的免疫失衡。

To study the role of IL-33, its receptor suppression of tumorigenicity 2 (ST2) and related cytokines in patients with non-small cell lung cancer(NSCLC), 30 patients with NSCLC were enrolled as case group, and 40 healthy controls were collected as control group. The mRNA and protein levels of IL-33 and ST2 in NSCLC tissues were detected by PCR and immunohistochemistry; The serum levels of IL-33/soluble ST2(sST2), IFN-γ, IL-4, IL-10 and IL-17A were detected by ELISA; The Pearson method was used to analyze the correlation between IL-33 and IL-4, IFN-γ, IL-10 and IL-17A in serum of NSCLC patients. Compared with the control group, mRNA and protein levels of IL-33 and ST2 in NSCLC patients were significantly increased (P＜0.05); Serum IL-33, sST2, IL-10, IL-17A and IL-4 levels were also significantly increased, while the level of IFN-γ was decreased (P＜0.05); the serum IL-33 level was positively correlated with the levels of IL-4 and IL-10 (r=0.65, P＜0.01; r=0.77, P＜0.01), and had a significant negative correlation with the level of IFN-γ (r=-0.82, P＜0.01), but not related to the level of IL-17A. Thus, increased levels of IL-33 and its receptor ST2 in NSCLC patients may cause the Th1/Th2 cytokine immune imbalance.